Synthesis and biological characterization of organoruthenium complexes with 8-hydroxyquinolines

Herein we present the study of the cytotoxic potential and apoptosis induction of a series of organoruthenium 8-hydroxyquinolinato complexes. Bromo substituted ligands gave best preliminary cytotoxicity results. Apoptosis induction results are in agreement with the cell viability assays. The most toxic compounds displayed IC50 values in the low micromolar range.50