Synthetic investigation of binary-ternary Cr(III)-hydroxycarboxylic acid-aromatic chelator systems. Structure-specific influence on adipogenic biomarkers linked to insulin mimesis

Aqueous synthetic reactivity in Cr(III)-(HA = hydroxycarboxylic acid)-(N,N-aromatic chelator = phen) (HA = heidaH2/quinic acid) systems afforded new well-defined pH-structural variants. Physicochemical characterization of all compounds led to structurally-distinct Cr(III) atoxic species investigated in vitro for their adipogenic capacity. The results support structure-specific interactions of Cr(III) with insulin-resistance biomarkers, thereby prompting for development of adipogenic metallodrugs.278