Biophysical characterization of Aptenodytes forsteri cytochrome P450 aromatase

The putative Aptenodytes forsteri (Emperor penguin) aromatase catalyzes the transformation of androstenedione to estrone through the same steroidal intermediates utilized by the human enzyme and pre-steady state analyses of their binding kinetics reveal that these, as well as the inhibitor anastrozole, utilize a multi-step mechanism.208