Chloro(triphenylphosphine)gold(I) a forefront reagent in gold chemistry as apoptotic agent for cancer cells

The activity against human breast adenocarcinoma (MCF-7) and normal human fetal lung fibroblast (MRC-5) cells of [Au(tpp)Cl] (1) (tpp = triphenylphosphine) was investigated. Cell cycle arrest, flow cytometry, permeabilization of the mitochondrial membrane assays and the catalytic oxidation of linoleic acid confirm the apoptotic cells death caused by 1.86