Inhibition of adhesion, migration and of α5β1 integrin in the HCT-116 colorectal cancer cells treated with the ruthenium drug NAMI-A

NAMI-A (imidazolium trans-imidazoledimethylsulfoxidetetrachlororuthenate) inhibits adhesion and migration of HCT-116 colorectal cells to fibronectin by down-regulating α5β1 integrin expression and activation through Tyr397-FAK (Focal Adhesion Kinase) auto-phosphorylation.177