Tetracarboxylatoplatinum(IV) complexes featuring monodentate leaving groups - A rational approach toward exploiting the platinum(IV) prodrug strategy

Novel symmetrically and unsymmetrically coordinated platinum(IV) complexes with monodentate carboxylato ligands were synthesized and characterized. Most lipophilic platinum(IV) complexes showed promising IC50 values in the low micromolar and even nanomolar range demonstrating the significant advantage of using equatorially coordinated monodentate carboxylato ligands.101