Second- and higher-order structural changes of DNA induced by antitumor-active tetrazolato-bridged dinuclear platinum(II) complexes with different types of 5-substituent

The second- and higher-order DNA structural changes were monitored upon addition of antitumor tetrazolato-bridged dinuclear platinum(II) complexes with different types of 5-substituent, using circular dichroism and fluorescence microscopy. The types of 5-substituent exert unique or different magnitudes of influence on the second-order structure, which is not necessarily linked to higher-order ones.