کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
7756235 | 1499793 | 2018 | 27 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Organotin(IV) 4-(benzo[d][1,3]dioxol-5-ylmethyl)piperazine-1-carbodithioates: Synthesis, characterization and biological activities
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی معدنی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Organotin(IV) 4-(benzo[d][1,3]dioxol-5-ylmethyl)piperazine-1-carbodithioates: Synthesis, characterization and biological activities Organotin(IV) 4-(benzo[d][1,3]dioxol-5-ylmethyl)piperazine-1-carbodithioates: Synthesis, characterization and biological activities](/preview/png/7756235.png)
چکیده انگلیسی
A series of organotin(IV) derivatives R3SnL (1-3), R2SnLCl (4-6) and R2SnL2 (7-9) (where Râ¯=â¯Me, Bu, Ph and Lâ¯=â¯4-(benzo[d][1,3]dioxol-5-ylmethyl)piperazine-1-carbodithioate) were prepared from the reaction of 4-(benzo[d][1,3]dioxol-5-ylmethyl)piperazine-1-carbodithioate (L-salt) with the corresponding triorganotin(IV) chlorides and diorganotin(IV) dichlorides. All compounds were characterized by FT-IR, 1H, 13C and 119Sn NMR spectroscopy. Dimethylstannyl bis(4-(benzo[d][1,3]dioxol-5-ylmethyl)piperazine-1-carbodithioate) (7) was also characterized in the solid state by single crystal x-ray diffraction, showing a distorted octahedral geometry. The diorganotin(IV) derivatives have shown significant antibacterial and antifungal activity and good cytotoxic activity against ovarian cancer cells with IC50 values greater or comparable to that of cisplatin.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Organometallic Chemistry - Volume 856, 1 February 2018, Pages 13-22
Journal: Journal of Organometallic Chemistry - Volume 856, 1 February 2018, Pages 13-22
نویسندگان
Farzana Shaheen, Muhammad Sirajuddin, Saqib Ali, Zia-ur-Rehman Zia-ur-Rehman, Paul J. Dyson, Naseer Ali Shah, Muhammad Nawaz Tahir,