Synthesis and characterization of nanoapatites organofunctionalized with aminotriphosphonate agents

► Surface functionalized hydroxyapatite nanoparticles are prepared from natural phosphate rock in a one-step process. ► Covalent grafting of amine phosphonates to the nanoparticle surface is simultaneously accomplished by the presence of the organic molecules in the solution. ► Mesoporous particles of high surface area are created. ► Surface coverage is controlled by the concentration of amine phosphonate.