Exploration of bivalent ligands targeting putative mu opioid receptor and chemokine receptor CCR5 dimerization

Compound 1b, Ki (MOR) = 3.24 nM; Ki (CCR5) = 239 nM; more effective in inhibiting HIV-1 entry in astrocytes compared to maraviroc alone or mixture of maraviroc and naltrexone with presence of morphine.184