کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
7781592 1500560 2018 34 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Immune-enhancing activities of chondroitin sulfate in murine macrophage RAW 264.7 cells
ترجمه فارسی عنوان
فعالیت های تقویت کننده ایمنی سولفات کاندرویتین در ماکروفاژهای چربی سلول های خونی 264.7
کلمات کلیدی
کندرویتین سولفات، فعالیت ایمن سازی ماکروفاژ، گیرنده غشای سلولی، گیرنده های توخالی،
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
چکیده انگلیسی
As a representative sulfated glycosaminoglycan (GAG), chondroitin sulfate (CS) has been reported playing vital roles in the immune response in vivo and in vitro. However, limited information is available about their immune-enhancing activity. This study was to achieve more precise understandings about the immuno-stimulating activity of CS. In in vitro experiments, CS was found to significantly promote the pinocytic, phagocytic activity and ROS production of RAW264.7 cells at the dose range of 100-1000 μg/mL compared with the untreated group (p < 0.05). Further experiments showed that CS could increase the secretion levels of NO, TNF-α, IL-6 and IL-10 via activating the corresponding mRNA expression in macrophages through the toll-like receptor 2 (TLR2). These results indicated that CS could function as an immunostimulator to enhance the immune responses and might be a potential candidate for application in immunological diseases or functional foods.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Carbohydrate Polymers - Volume 198, 15 October 2018, Pages 611-619
نویسندگان
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