کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
7781680 1500561 2018 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Fabrication and biocompatibility of agarose acetate nanofibrous membrane by electrospinning
ترجمه فارسی عنوان
ساخت و سازگاری بیولوژیکی غشاء نانوفارل آگارز استات با الکتروفیزین
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
چکیده انگلیسی
In the present paper, agarose acetate (AGA) nanofibrous membranes containing different weight percentages of β-tricalcium phosphate (β-TCP) were successfully developed through electrospinning. The fibers in the nanofibrous membranes had a rough surface due to the β-TCP particles which were uniformly dispersed within or on the surface of AGA fibers. Rat-bone marrow-derived mesenchymal stem cells (rBMSCs) were cultured on the AGA based nanofibrous membranes while showed a good adhesion and proliferation. It was found that more rBMSCs were differentiated to osteoblast-like cells on the β-TCP containing nanofibrous membranes compared with the single AGA membrane, and more alkaline phosphatase (ALP) and mineralized matrix could be detected when rBMSCs were cultured on the β-TCP containing nanofibrous membranes. The nanofibrous membranes were implanted into Sprague-Dawley (SD) rats for biocompatibility test. Gross examination and histological analysis of the AGA based nanofibrous membranes results showed that there was less inflammatory response. All of experimental results suggested that the AGA based nanofibrous membranes had the great potential application in bone tissue engineering.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Carbohydrate Polymers - Volume 197, 1 October 2018, Pages 237-245
نویسندگان
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