کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
7783804 | 1500574 | 2018 | 11 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Novel organic/inorganic hybrid flower-like structure of selenium nanoparticles stabilized by pullulan derivatives
ترجمه فارسی عنوان
ساختار سلولزی سلنیوم که با ترکیبات پلولان تثبیت شده است، ریخته شده است
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کلمات کلیدی
گل های ترکیبی نانوذرات سلنیوم، پلولان، سمیت مسمومیت، مکانیزم تشکیل
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
چکیده انگلیسی
We proudly present the first organic/inorganic hybrid pullulan/SeNPs hybrid microflower material obtained using a simple and bio-inspired strategy. The chemical structures of pullulan, folic acid decorated cationic pullulan (FA-CP) were designed for stabilizing selenium nanoparticles (SeNPs). SeNPs stabilized by FA-CP hybrid microflowers were observed after the addition of a cysteine hydrochloride solution into the solution mixture of Na2SeO3 and FA-CP. We suggested that the concentrations of cysteine and FA-CP were the key factors for the formation of flower-like structure. In addition, the formation mechanism of the microflowers was tentatively identified as anisotropic hierarchical growth. The microflowers exhibited effective drug adsorption with the loading capacity of 142.2â¯mgâ¯gâ1 for doxorubicin which was three times higher than that for the doxorubicin-loaded spherical SeNPs and showed more potent activity against cancer cells while showing less toxicity against normal cells. These data demonstrated that the microflower-like FA-CP/SeNPs structure could be a candidate anticancer drug template in drug delivery systems.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Carbohydrate Polymers - Volume 184, 15 March 2018, Pages 9-19
Journal: Carbohydrate Polymers - Volume 184, 15 March 2018, Pages 9-19
نویسندگان
Punnida Nonsuwan, Songchan Puthong, Tanapat Palaga, Nongnuj Muangsin,