کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
7783988 | 1500574 | 2018 | 39 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
γ-Cyclodextrin-phenylacetic acid mesh as a drug trap
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موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
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چکیده انگلیسی
In this study, we developed a nanoporous biodegradable mesh, bioinspired by the spider web, which is prepared via electrospinning using γ-cyclodextrin (γ-CD) conjugated with phenylacetic acid (PA), named γ-CDP. The resulting γ-CDP has a microfibrous or microspherical shape and contains drug trap meshlike γ-CD pores. These γ-CDP micromeshes (microspheres or microfibers) enable efficient drug capture and drug transport into deep γ-CDP nanocompartments or out of the γ-CDP web, resulting in a driving domain for a 4-week drug release. When used to deliver chemotherapeutic agents to xenografted tumors, the γ-CDP implants caused nearly complete tumor regression for 4 weeks after single administration. This strategy of a drug trap biodegradable mesh (with low density) will make drug containers uniquely attractive for the development of therapeutic implants and functional biomedical devices.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Carbohydrate Polymers - Volume 184, 15 March 2018, Pages 390-400
Journal: Carbohydrate Polymers - Volume 184, 15 March 2018, Pages 390-400
نویسندگان
Hyeong Sup Yu, Jae Min Lee, Yu Seok Youn, Kyung Taek Oh, Kun Na, Eun Seong Lee,