کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
7785125 | 1500605 | 2016 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The comparison of structure and anticancer activity in vitro of polysaccharides from brown algae Alaria marginata and A. angusta
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Laminaran and three fucoidan fractions were obtained from the brown alga Alaria marginata. Alaria angusta, studied earlier by us, has the same polysaccharide composition. Galactofucan AmF3 from A. marginata has a main chain of â 3)-α-l-Fucp-(2,4-SO3â)-(1 â residues, similar to galactofucan from A. angusta. However, the structure of the branches in fucoidan AmF3 can differ from those in the fucoidan from A. angusta. The following fragments were identified in AmF3: HexA-(1 â 2)-Fuc, HexA-(1 â 2)-Gal, Gal-(1 â 4)-HexA, Fuc-(1 â 2)-Gal-6-SO3â, Fuc-4-SO3â-(1 â 6)-Gal, Gal-(1 â 2)-Gal-2-SO3â, Gal-4-SO3â-(1 ââ 6)-Gal, Gal-4-SO3â-(1 â 3)-Fuc-(1 â 3)-Fuc, Fuc-4-SO3â-(1 â 6)-Gal-(1 â 4)-Gal, Gal-(1 â 4)-Gal-(1 â 3)-Fuc, Gal-2-SO3â-(1 â 4)-Gal-(1 â 4)-Gal, Gal-(1 â 4)-Gal-6-SO3â-(1 â 2)-Gal. Chains of galactose residues (DP up to 9) were found in AmF3 fucoidan. The laminarans, galactofucans and their derivatives from both algae exhibited no cytotoxicity in vitro. Polysaccharides from A. angusta were more effective against colony formation of HT-29 cells, while those from A. marginata had a greater effect on T-47D cells. Sulfated and desulfated fucoidans possessed weak antitumor activity using SK-MEL-28 cells.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Carbohydrate Polymers - Volume 153, 20 November 2016, Pages 258-265
Journal: Carbohydrate Polymers - Volume 153, 20 November 2016, Pages 258-265
نویسندگان
Roza V. Usoltseva (Menshova), Stanislav D. Anastyuk, Natalia M. Shevchenko, Tatiana N. Zvyagintseva, Svetlana P. Ermakova,