کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
7785213 | 1500605 | 2016 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Facile approach to prepare drug-loading film from hemicelluloses and chitosan
ترجمه فارسی عنوان
رویکرد تکه برای تهیه فیلم بارگیری مواد مخدر از همی سلولز و کیتوزان
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
چکیده انگلیسی
This study introduces a facile and green route to fabricate film from bio-based polymers. The film has been prepared by the cross-linking reaction of quaternized hemicelluloses (QH) and chitosan (CHO) with epichlorohydrin (ECH) as crosslinker. It exhibits an excellently mechanical performance as a result of its high tensile strength (up to 37Â MPa). Importantly, the roughness of film was 2-5Â nm in the area of 400Â nm, and smooth surface with pores were presented on the film based on the results of scanning electron microscope (SEM) and atomic force microscope (AFM). Ciprofloxacin was utilized as a mode compound to investigate the loading behavior of the film, and the highest loading concentration was about 18%. The drug release was about 20% in film1 in comparison to only 15% in film3 within 48Â h. Furthermore, the results of a 293T cell viability assay indicated its good biocompatibility and non-toxicity.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Carbohydrate Polymers - Volume 153, 20 November 2016, Pages 542-548
Journal: Carbohydrate Polymers - Volume 153, 20 November 2016, Pages 542-548
نویسندگان
Ying Guan, Xian-Ming Qi, Ge-Gu Chen, Feng Peng, Run-Cang Sun,