کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
7785371 | 1500609 | 2016 | 29 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Antibiofilm activity of carboxymethyl chitosan on the biofilms of non-Candida albicans Candida species
ترجمه فارسی عنوان
فعالیت آنتی بیوفیلم کربوکسی متیل کیتوزان بر روی بیوفیلم گونه های غیر کاندیدا آلبیکنس کاندیدا
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موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
چکیده انگلیسی
Although most cases of candidiasis have been attributed to Candida albicans, non-C. albicans Candida species have been isolated in increasing numbers in patients. In this study, we determined the inhibition of carboxymethyl chitosan (CM-chitosan) on single and mixed species biofilm of non-albicans Candida species, including Candida tropicalis, Candida parapsilosis, Candida krusei and Candida glabrata. Biofilm by all tested species in microtiter plates were inhibited nearly 70%. CM-chitosan inhibited mixed species biofilm in microtiter plates and also on medical materials surfaces. To investigate the mechanism, the effect of CM-chitosan on cell viability and biofilm growth was employed. CM-chitosan inhibited Candida planktonic growth as well as adhesion. Further biofilm formation was inhibited with CM-chitosan added at 90Â min, 12Â h or 24Â h after biofilm initiation. CM-chitosan was not only able to inhibit the metabolic activity of Candida cells, but was also active upon the establishment and the development of biofilms.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Carbohydrate Polymers - Volume 149, 20 September 2016, Pages 77-82
Journal: Carbohydrate Polymers - Volume 149, 20 September 2016, Pages 77-82
نویسندگان
Yulong Tan, Matthias Leonhard, Doris Moser, Berit Schneider-Stickler,