کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
7786123 | 1500614 | 2016 | 35 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Self assembled hyaluronic acid nanoparticles as a potential carrier for targeting the inflamed intestinal mucosa
ترجمه فارسی عنوان
نانوذرات اسید هیالورونیک خود را به عنوان یک حامل بالقوه برای هدف قرار دادن مخاط روده
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کلمات کلیدی
نانوسیمهای خودمراقبتی، اسید هیالورونیک، تحویل دارو هدفمند، بیماری روده التهابی بودسونید،
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
چکیده انگلیسی
To develop a nanoparticulate drug carrier for targeting of the inflamed intestinal mucosa, amphiphilic hyaluronic acid (HA) conjugates were synthesized, which could form self-assembled nanoparticles (NPs) in aqueous solution and budesonide (BDS) was loaded into the HANPs. Their particle sizes were in the range of 177 to 293 nm with negative surface charge. The model of inflammatory CACO-2 cells was utilized to investigate the therapeutic potential of budesonide loaded HA nanocarriers. The highest expression of CD44 receptors was found on inflamed Caco-2 cells, as determined by flow cytometry. FITC-labeled HANPs revealed greater uptake in inflamed CACO-2 cells compared to untreated CACO-2 and CD44-negative cell lines, NIH3T3. BDS loaded HANPs displayed almost no toxicity indicating HANPs are excellent biocompatible nano-carriers. BDS loaded HANPs demonstrated higher anti-inflammatory effect on IL-8 and TNF-α secretion in inflamed cell model compared to the same dose of free drug. These results revealed the promising potential of HA nanoparticles as a targeted drug delivery system for IBD treatment.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Carbohydrate Polymers - Volume 144, 25 June 2016, Pages 371-381
Journal: Carbohydrate Polymers - Volume 144, 25 June 2016, Pages 371-381
نویسندگان
Seyed Yaser Vafaei, Motahareh Esmaeili, Mohsen Amini, Fatemeh Atyabi, Seyed Naser Ostad, Rassoul Dinarvand,