کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
7788984 | 1500635 | 2015 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The supramolecular structure of LPS-chitosan complexes of varied composition in relation to their biological activity
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: The supramolecular structure of LPS-chitosan complexes of varied composition in relation to their biological activity The supramolecular structure of LPS-chitosan complexes of varied composition in relation to their biological activity](/preview/png/7788984.png)
چکیده انگلیسی
The complexes of chitosan (Ch) with lipopolysaccharides (LPSs) from Escherichia coli O55:B5 (E-LPS) and Yersinia pseudotuberculosis 1B 598 (Y-LPS) of various weight compositions were investigated using quasi-elastic light scattering, ζ-potential distribution assay and atomic force microscopy. The alteration of ζ-potential of E-LPS-Ch complexes from negative to positive values depending on Ch content was detected. The Y-LPS-Ch complexes had similar positive ζ-potentials regardless of Ch content. The transformation of the supramolecular structure of E-LPS after binding with to Ch was revealed. Screening of E-LPS and Y-LPS particles by Ch in the complexes with high polycation was detected. The ability of LPS-Ch complex to induce biosynthesis of TNF-α and reactive oxygen species in stimulated human mononuclear cells was studied. A significant decrease in activity complexes compared to that of the initial LPS was observed only for E-LPS-Ch complexes.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Carbohydrate Polymers - Volume 123, 5 June 2015, Pages 115-121
Journal: Carbohydrate Polymers - Volume 123, 5 June 2015, Pages 115-121
نویسندگان
V.N. Davydova, A.V. Volod'ko, E.V. Sokolova, E.A. Chusovitin, S.A. Balagan, V.I. Gorbach, N.G. Galkin, I.M. Yermak, T.F. Solov'eva,