کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
7789214 | 1500636 | 2015 | 13 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Low molecular weight heparin mediating targeting of lymph node metastasis based on nanoliposome and enzyme-substrate interaction
ترجمه فارسی عنوان
هپارین با وزن مولکولی پایین میانجیگری هدف متاستاز غدد لنفاوی مبتنی بر نانولایپوزوم و تعامل آنزیم سوبسترا
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کلمات کلیدی
هپارین کم مولکولی هپارناز، نانولیپوزوم، هدف گذاری، متاستاز گره لنفاوی،
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
چکیده انگلیسی
The aim of our study is to develop a new function of low molecular weight heparin (LMWHEP) for targeting tumor metastatic lymph node based on LMWHEP-modified nanoliposome and LMWHEP-heparanase (HPA) interaction (LMWHEP-HPA). At First, LMWHEP-modified nanoliposomes (LMWHEP-LPs) were prepared by the electrostatic attraction and the physiochemical properties were evaluated. Then the effects of LMWHEP-HPA on the stability and drug release were investigated. In addition, the cellular uptake of LMWHEP-LPs was studied by using Hela, MCF-7, L929 and RAW264.7 cells. Finally, the targeting ability as well as the tissue distribution was examined in the mice model bearing Hela tumor lymph node metastasis. LMWHEP-LPs prepared had suitable physicochemical properties. The effect results of LMWHEP-HPA showed that LMWHEP coated on the surface of nanoliposome could be degraded by HPA. Compared with the unmodified-nanoliposome, the LMWHEP modification could improve the cellular uptake and increase the targeting ability to the metastatic lymph nodes according to LMWHEP-HPA. This study demonstrates LMWHEP is a highly promising polymer material for the targeting of tumor lymph node metastasis.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Carbohydrate Polymers - Volume 122, 20 May 2015, Pages 26-38
Journal: Carbohydrate Polymers - Volume 122, 20 May 2015, Pages 26-38
نویسندگان
Tiantian Ye, Xuewei Jiang, Jing Li, Rui Yang, Yuling Mao, Kai Li, Liang Li, Fen Chen, Jianhua Yao, Yingliang Wu, Xinggang Yang, Shujun Wang, Weisan Pan,