کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
7789241 | 1500636 | 2015 | 12 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Fabrication of cyclodextrins-procainamide supramolecular self-assembly: Shape-shifting of nanosheet into microtubular structure
ترجمه فارسی عنوان
ساخت ساختار خودمراقبتی سوپرملولکولی سیکلوکودکسترین-پروینامیندها: تبدیل شکل نانوساختار به ساختار میکرو لوله ای
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
چکیده انگلیسی
Encapsulation behavior of α- and β-cyclodextrins (α-CD, β-CD) with procainamide hydrochloride (PCA) has been investigated by absorption, fluorescence, time-resolved fluorescence, proton nuclear magnetic resonance spectroscopy, scanning electron microscope, Fourier transform-infrared spectroscopy, differential scanning calorimetry, and powder X-ray diffraction techniques. Spectral results revealed that PCA forms 1:2 drug-CD2 inclusion complexes with CDs. Novel supramolecular self-assemblies have been fabricated by inclusion complexation of PCA with α-CD/β-CD and characterized by transmission electron microscope and micro-Raman imaging. The obtained results from transmission electron microscope indicated that PCA/α-CD complex could form nano-sized particles. However, when the macrocyclic ring with six glucose units was switched into seven glucose units, the resultant PCA/β-CD complex could be self-assembled to micro-sized tubular structures. Shape-shifting of 2D nanosheet into 1D microtube by simple rolling mechanism was analyzed. Thermodynamic parameters of inclusion process were determined by Parameter Method 3 calculations.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Carbohydrate Polymers - Volume 122, 20 May 2015, Pages 123-134
Journal: Carbohydrate Polymers - Volume 122, 20 May 2015, Pages 123-134
نویسندگان
S. Siva, S. Kothai Nayaki, N. Rajendiran,