کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
7790094 1500643 2015 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Development of tannic acid/chitosan/pullulan composite nanofibers from aqueous solution for potential applications as wound dressing
ترجمه فارسی عنوان
توسعه نانو فیبرهای کامپوزیت اسید / کیتوزان / پیلولان از محلول آبی برای استفاده های بالقوه مانند پانسمان زخم
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
چکیده انگلیسی
This study presents the successful development of biocompatible tannic acid (TA)/chitosan (CS)/pullulan (PL) composite nanofibers (NFs) with synergistic antibacterial activity against the Gram-negative bacteria Escherichia coli. The NFs were developed utilizing the forcespinning® (FS) technique from CS-CA aqueous solutions to avoid the usage of toxic organic solvents. The ternary nanofibrous membranes were crosslinked to become water stable for potential applications as wound dressing. The morphology, structure, water solubility, water absorption capability and thermal properties of the NFs were characterized. The ternary composite membrane exhibits good water absorption ability with rapid uptake rate. This novel membrane favors fibroblast cell attachment and growth by providing a 3D environment which mimics the extracellular matrix (ECM) in skin and allows cells to move through the fibrous structure resulting in interlayer growth throughout the membrane, thus favoring potential for deep and intricate wound healing.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Carbohydrate Polymers - Volume 115, 22 January 2015, Pages 16-24
نویسندگان
, , , , ,