کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
7790957 1500646 2014 32 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The excreted polysaccharide of Pleurotus eryngii inhibits the foam-cell formation via down-regulation of CD36
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
The excreted polysaccharide of Pleurotus eryngii inhibits the foam-cell formation via down-regulation of CD36
چکیده انگلیسی
Previous study has verified the polysaccharide from the fruiting body of Pleurotus eryngii (PEPE) is capable of decreasing the lipid content in both of cell-line and mouse model. However, little is known about underlying mechanisms and whether this bioactive polysaccharide exists in submerged culture. Here, we verified the excreted polysaccharides EP and EP-1 from submersion culture of P. eryngii have the remarkable inhibitory effects on lipid accumulation in macrophage-derived foam cells. Structure analysis indicates EP-1 consists of d-types of glucose, galactose and mannose with the main β(1 → 3)-glucan glycosidic linkage branched at O-6 by α-d-glucose while EP digested by β-1,3-glucanase fails to decrease the lipid accumulation, suggesting that the special structure is essential for its function. Expression analysis suggests that EP is able to cause the down-regulation of the scavenger receptor-CD36 on both transcription and protein levels. Most importantly, EP can be obtained by fermentation in a mass-production.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Carbohydrate Polymers - Volume 112, 4 November 2014, Pages 16-23
نویسندگان
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