کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
7790985 | 1500645 | 2014 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Characterisation of biodegradable pectin aerogels and their potential use as drug carriers
ترجمه فارسی عنوان
ویژگی های آلیاژل های پکتین تجزیه پذیر و قابلیت استفاده بالقوه آنها به عنوان دارنده های دارویی
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
چکیده انگلیسی
The purpose of this work was to prepare stable citrus (CF) and apple (AF) pectin aerogels for potential pharmaceutical applications. Different shapes of low ester pectin aerogels were prepared by two fundamental methods of ionic cross-linking. Pectins' spherical and multi-membrane gels were first formed by the diffusion method using 0.2Â M CaCl2 solution as an ionic cross-linker. The highest specific surface area (593Â m2/g) that had so far been reported for pectin aerogels was achieved using this method. Monolithic pectin gels were formed by the internal setting method. Pectin gels were further converted into aerogels by supercritical drying using CO2. As surface area/volume is one of the key parameters in controlling drug release, multi-membrane pectin aerogels were further used as drug delivery carriers. Theophylline and nicotinic acid were used as model drugs for the dissolution study. CF aerogels showed more controlled release behaviour than AF pectin aerogels. Moreover a higher release rate (100%) was observed with CF aerogels.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Carbohydrate Polymers - Volume 113, 26 November 2014, Pages 272-278
Journal: Carbohydrate Polymers - Volume 113, 26 November 2014, Pages 272-278
نویسندگان
Anja Veronovski, Gabrijela Tkalec, Željko Knez, Zoran Novak,