کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
7792519 1500656 2014 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
In situ gelling dorzolamide loaded chitosan nanoparticles for the treatment of glaucoma
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
In situ gelling dorzolamide loaded chitosan nanoparticles for the treatment of glaucoma
چکیده انگلیسی
The most important risk associated with glaucoma is the onset and progression of intraocular pressure. The objective of this study was to formulate in situ gel of chitosan nanoparticles to enhance the bioavailability and efficacy of dorzolamide in the glaucoma treatment. Optimized nanoparticles were spherical in shape (particle size: 164 nm) with a loading efficiency of 98.1%. The ex vivo release of the optimized in situ gel nanoparticle formulation showed a sustained drug release as compared to marketed formulation. The gamma scintigraphic study of prepared in situ nanoparticle gel showed good corneal retention compared to marketed formulation. HET-CAM assay of the prepared formulation scored 0.33 in 5 min which indicates the non-irritant property of the formulation. Thus in situ gel of dorzolamide hydrochloride loaded nanoparticles offers a more intensive treatment of glaucoma and a better patient compliance as it requires fewer applications per day compared to conventional eye drops.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Carbohydrate Polymers - Volume 102, 15 February 2014, Pages 117-124
نویسندگان
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