کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
7792777 | 1500657 | 2014 | 11 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Structure and anti-metapneumovirus activity of sulfated galactans from the red seaweed Cryptonemia seminervis
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Structure and anti-metapneumovirus activity of sulfated galactans from the red seaweed Cryptonemia seminervis Structure and anti-metapneumovirus activity of sulfated galactans from the red seaweed Cryptonemia seminervis](/preview/png/7792777.png)
چکیده انگلیسی
The anti-HMPV (human metapneumovirus) activity was determined for sulfated dl-hybrid galactans obtained from the red seaweed Cryptonemia seminervis and their depolymerized products obtained by reductive partial hydrolysis. Structural studies carried out in three homogeneous depolymerized fractions DS-1, DS-2e and DS-3 (Mw of 51.6-63.8 kDa) showed that these galactans present different chemical characteristics, as monosaccharide composition, content of sulfate groups (14.1-29.9%) and agaran:carrageenan molar ratio diads, 2.7:1 for DS-1 and DS-2e and 1:1 for DS-3. The sulfate groups are located principally on C-2 of β-d-galactopyranose and 4,6-O-(1â²-carboxyethylidene)-β-d-galactopyranose residues and on C-6 of α-galactose residues. Sulfated dl-galactans and their depolymerized products exhibited antiviral activity at a very early stage of the viral infection cycle. All fractions, except DS-2e inhibited HMPV replication by binding to the viral particle. Besides depolymerized galactans DS-2e and DS-3 inhibited the recognition of cell receptor by HMPV and penetration to the host cell, respectively.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Carbohydrate Polymers - Volume 101, 30 January 2014, Pages 313-323
Journal: Carbohydrate Polymers - Volume 101, 30 January 2014, Pages 313-323
نویسندگان
Gabriella S. Mendes, Maria E.R. Duarte, Franciely G. Colodi, Miguel D. Noseda, Luciana G. Ferreira, Siliane D. Berté, Jéssica F. Cavalcanti, Norma Santos, Maria T.V. Romanos,