Non-covalent hydrogels of cyclodextrins and poloxamines for the controlled release of proteins

- Direct and reverse poloxamines yield supramolecular gels with α-CD but solid precipitates with β-CD.
- The rheological behaviour depends on the copolymer/oligosaccharide ratio and the temperature.
- Proteins or other molecules can be loaded into these supramolecular structures before gelation.
- Controlled release of entrapped proteins is feasible and tuned varying the copolymer/CD ratio.