کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
7793551 | 1500659 | 2014 | 37 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Synthesis and cardio protective biological applications of glucodendrimers by H9C2 cell studies
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Synthesis and cardio protective biological applications of glucodendrimers by H9C2 cell studies Synthesis and cardio protective biological applications of glucodendrimers by H9C2 cell studies](/preview/png/7793551.png)
چکیده انگلیسی
Novel glucodendrimers scaffolds containing α-d-glucopyranoside at the surface and triazole as bridging unit have been synthesized. Cardiomyocytes were exposed to normal and high glucose level in the presence and absence of glucodendrimers. Cytotoxicity studies were also carried out and the expression of metalloproteinases mainly MMP-2 and 9 was confirmed with gelatine zymography and RT-PCR gene expression studies. Cardio protective efficiency of the synthesized glucodendrimers against high glucose induced toxicity on mettalloproteinase-2 and 9 and also on H9C2 cell lines revealed that higher generation glucodendrimers 6 and 8 are more effective than the lower generation glucodendrimers.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Carbohydrate Polymers - Volume 99, 2 January 2014, Pages 403-414
Journal: Carbohydrate Polymers - Volume 99, 2 January 2014, Pages 403-414
نویسندگان
Perumal Rajakumar, Ramasamy Anandhan, Gangadhara Prasadachari Vadla, Elangovan Vellaichamy,