کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
7795094 | 1500895 | 2012 | 13 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Carbohydrate-based synthetic ion transporters
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کلمات کلیدی
TEGEYPGHPTSGlycomimeticsEYPCDIEADMFTFATHFHEPES4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid - 4- (2-hydroxyethyl) -1-piperazineethanesulfonic acidN,N-dimethylformamide - N، N-dimethylformamideN,N-diisopropylethylamine - N، N-دییزوپروپیلتیلامینAmphiphilic cyclodextrins - آمفیفیلی سیکلوکودرکسترینTrifluoroacetic acid - اسید Trifluoroaceticlarge unilamellar vesicles - بزرگ کیسه های بدون انعطاف پذیرbenzoyl chloride - بنزوئیل کلریدBenzyl - بنزیلTetrahydrofuran - تتراهیدروفورانtriethylamine - تری اتیلامینTriethylene glycol - تری اتیلن گلیکولion transporters - حمل کننده یونLUV - لووMacrocycles - ماکروسیکل هاTEA - چای
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
In this work, carbohydrate-based systems designed as artificial ion transporters have been surveyed. Despite the large structural diversity and ease of manipulations of carbohydrates, in principle endowed with a variety of desirable properties for ionophoric activity, only few examples of sugar-containing compounds have been reported in the literature for these purposes. The most remarkable example is the family of modified β-cyclodextrins, resulting in active cation and/or anion transporters when long, flexible n-alkyl or oligo-ethylene or butylene glycol chains are appended at the lower rim of the macrocycle. Interesting features have been also found in amphiphilic CyPLOS (Cyclic Phosphate-Linked Oligosaccharide) dimers, that is macrocycles with two phenyl-β-d-glucopyranoside residues, 4,6-linked through phosphodiester bonds, derivatized with tetraethylene glycol tentacles. A wider repertoire of available carbohydrate-based scaffolds is expected to largely stimulate the discovery of novel, efficient artificial ionophores, of great interest for both technological and biomedical applications.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Carbohydrate Research - Volume 356, 15 July 2012, Pages 62-74
Journal: Carbohydrate Research - Volume 356, 15 July 2012, Pages 62-74
نویسندگان
Daniela Montesarchio, Cinzia Coppola, Mariangela Boccalon, Paolo Tecilla,