Synthesis, characterization, antimicrobial activity, carbonic anhydrase enzyme inhibitor effects, and computational studies on new Schiff bases of Sulfa drugs and their Pd(II), Cu(II) complexes

New Schiff bases (E)N-(3,4-dimethylisoxazol-5-yl)-4-((2-hydroxy-3-methoxybenzylidene) amino)benzenesulfonamide (Ll), (E)N-(3,4-dimethylisoxazol-5-yl)-4-((2-hydroxy-4-methoxybenzylidene)amino)benzenesulfonamide (L2) and (E)-4-((4-methoxy-2-hydroxybenzylidene)amino)N-(5-methylisoxazol-3-yl)benzene sulfonamide (L3) derived from sulfamethoxazole (S1)/sulfisoxazole (S2) and substituted salicylaldehydes and their Pd (II), Cu (II) complexes were synthesized for the first time and investigated their antibacterial activities and carbonic anhydrase enzyme inhibitor effects. Also 1H and 13C shielding tensors for crystal structure were calculated with GIAO/DFT/B3LYP/6-311++G(d,p) methods in CDCl3.56