کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
7807448 1501654 2018 21 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Synthesis and crystal structure of quinolinium salt: Assignment on nonsteroidal anti-inflammatory activity and DNA cleavage activity
ترجمه فارسی عنوان
سنتز و ساختار کریستالی نمک کینولینیم: تعویض فعالیت ضد التهابی غیر استروئیدی و فعالیت برش دی ان ای
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
چکیده انگلیسی
To develop new anti-inflammatory and DNA cleavage agent with improved pharmaceutical profile, five quilinium salt based compounds have been synthesized and x-ray characterization of these quinolinium salts have been reported here. These quinolinium salts have potential to show the better anti-inflammatory activity as well as DNA cleavage activity. The anti-inflammatory activities of quinolinium salts 1-5 have been evaluated by complete Freund's adjuvant (CFA) induced rat paw edema method. The DNA cleavage activities of quinolinium salts 1-5 were analyzed by using plasmid pBR322. The crystal structure of quinolium salt 1, 2 and 3 have shown the intermolecular non-covalent interactions such as cation···π, π···π, CH···π, CH···X (X = I and Br) and CH⋯N interactions.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Molecular Structure - Volume 1163, 5 July 2018, Pages 262-269
نویسندگان
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