کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
7831603 | 1503272 | 2008 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Solution Structure of Conomarphin, a Novel Conopeptide Containing D-Amino Acid at pH 5
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی تئوریک و عملی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Solution Structure of Conomarphin, a Novel Conopeptide Containing D-Amino Acid at pH 5 Solution Structure of Conomarphin, a Novel Conopeptide Containing D-Amino Acid at pH 5](/preview/png/7831603.png)
چکیده انگلیسی
Conomarphin, a novel conopeptide containing D-amino acid, was identified from the venom of Conus marmoreus and classified into M-superfamily of conotoxin. In this article, we reported the 3D structure of conomarphin at pH 5 determined using 2D 1H NMR method in aqueous solution. Twenty converged structures of this peptide were obtained based on 205 distance constraints, 8 dihedral angle constraints, and 2 hydrogen bond constraints. The root mean square deviation (RMSD) values of the backbone atoms were (0.074±0.029) nm. The refined structure of conomarphin at pH 5 contains a short 310-helix at C-terminal of the peptide. It was also characterized by a loose loop centered at Ala6. Comparison of structural and electrostatic potential between conomarphin at pH 3 and pH 5 were presented. Although the solution structure of conomarphin at pH 5 shared part of the same secondary structure element with the structure of conomarphin at pH 3, it adopted a distinctive backbone conformation with the overall molecule resembling a “flexual arm” when viewed from the front. Structural differences implied that this conopeptide was rather pH sensitive and its bioactivity in vivo might be related to the acidity.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Acta Physico-Chimica Sinica - Volume 24, Issue 9, September 2008, Pages 1558-1562
Journal: Acta Physico-Chimica Sinica - Volume 24, Issue 9, September 2008, Pages 1558-1562
نویسندگان
Feijuan Huang, Weihong Du, Baohuai Wang,