کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
7841948 1506505 2018 32 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Physico-chemical characterization of drug-bio-surfactant micellar system: A road for developing better pharmaceutical formulations
ترجمه فارسی عنوان
خصوصیات فیزیکی و شیمیایی سیستم میسلر دارویی-بیو-سد-واکنش: راه برای تولید فرمولاسیون داروهای بهتر
کلمات کلیدی
بیو-سورفاکتانت، تجمع، غلظت ماکتل بحرانی، مایکولیزاسیون، مدل جدایی شبه فاز شارژ،
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی تئوریک و عملی
چکیده انگلیسی
The knowledge about the characteristics of drug - bio-surfactants system is crucial in pharmacology which helps to design better pharmaceutical formulations. The descriptions of the modulation in drug (metformin hydrochloride) - bio-surfactants (sodium cholate and sodium deoxycholate) mixture, in solution micellar phase has been accessed by means of critical micelle concentration (CMC) determination and thermodynamic approach through conductometric and spectroscopic techniques. The conductivity, κ data have been employed to determine critical micelle concentration, CMC i.e. point of aggregation and results have been discussed in terms of hydrophobic and electrostatic interactions present in the system. The obtained CMC values reveal the fact that the micellization tendency of studied bio-surfactant increases in the presence of drug. The conductivity study (CMC determination) has also been found to corroborate the results obtained from UV-visible (absorption spectra) and fluorescence (emission spectra) studies. Moreover, the temperature dependence of CMC values (typical U-shaped profile) has been explained in terms of various interactions present around the hydrophobic part of bile salts. Furthermore, charged pseudo-phase separation model of micellization has also been applied to grasp information on the intermolecular interactions existing in the present ternary system. The work may be considered a step towards making use of bile salts as a promising approach in drug delivery and increasing their bioavailability.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Molecular Liquids - Volume 266, 15 September 2018, Pages 692-702
نویسندگان
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