کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
7842346 | 1506507 | 2018 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Water and cold denaturation of small globular proteins
ترجمه فارسی عنوان
غلظت آب و سرد پروتئین های کوچک کروی
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی تئوریک و عملی
چکیده انگلیسی
Cold denaturation is an intriguing phenomenon that deserves special attention because its rationalization is surely linked to a deeper understanding of the molecular determinants of the marginal stability of small globular proteins dissolved in water and aqueous solutions. It is here reviewed and discussed a theoretical approach that has offered a reliable explanation for the occurrence of both cold and hot denaturations. A cornerstone of the approach is the recognition of the role played by the density of water and its temperature-dependence that are largely determined by the special energetic and geometric features of H-bonds. In fact, the density of water determines the magnitude of the solvent-excluded volume effect, which is a main ingredient of the hydrophobic effect. The relationship between density and solvent-excluded volume effect establishes a strong connection between the physico-chemical properties of water and the conformational stability of small globular proteins.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Molecular Liquids - Volume 264, 15 August 2018, Pages 579-584
Journal: Journal of Molecular Liquids - Volume 264, 15 August 2018, Pages 579-584
نویسندگان
Antonio Grimaldi, Giuseppe Graziano,