کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
7843159 1506517 2018 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Thermodynamic analysis of binding of benzimidazole derivative with cucurbit[7]uril: A isothermal titration calorimetry study
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی تئوریک و عملی
پیش نمایش صفحه اول مقاله
Thermodynamic analysis of binding of benzimidazole derivative with cucurbit[7]uril: A isothermal titration calorimetry study
چکیده انگلیسی
The isothermal titration calorimetry (ITC) is a direct method to measure the heat change due to the complex formation at a constant temperature. ITC technique is the most accurate technique to directly measure binding stoichiometry, binding constant, enthalpy change, and entropy change due to complex formation. In this work, we have used ITC technique to formulate the inclusion behavior of 2-(2′-Pyridyl)benzimidazole (2-PB) with water soluble macrocyclic host cucurbit[7]uril (CB7) at three different pH's. From ITC measurement, we obtained different thermodynamic parameters associated with 2-PB-CB7 complexation. We have explained thoroughly the driving forces involved for this complexation from ITC measurement. The binding constant and other different thermodynamic parameters involve for the inclusion of 2-PB inside the cavity of CB7 at three different pH's have been estimated by using ITC technique. It was observed that the strength of supramolecular complex gradually decreases with increasing the pH value of the medium.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Molecular Liquids - Volume 254, 15 March 2018, Pages 70-75
نویسندگان
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