Thermodynamics of solution and partition of dioxidine in water and the water/1-octanol biphasic system

We have studied for the first time the thermodynamic behavior of the well-established antimicrobial drug - dioxidine (2,3-dihydroxymethylquinoxaline-1,4-dioxide) in water and the water/1-octanol biphasic system. Enthalpies of solution and solubility of dioxidine were experimentally determined and exploited to compute thermodynamic functions of solution and the solubility of the drug in a wide temperature range. Partition coefficients between water and 1-octanol were also obtained to evaluate lipophilicity of dioxidine and used to compute thermodynamic functions of the solute transfer from water to aqueous octanol. The results are discussed in terms of solute-solvent interactions occurring in water-like and lipid-like phases.