Repurposing cationic amphiphilic drugs as adjuvants to induce lysosomal siRNA escape in nanogel transfected cells

Through functional inhibition of acid sphingomyelinase (ASM), cationic amphiphilic drugs (CADs) induce non-lethal lysosomal membrane permeabilization (LMP), enhancing the cytosolic delivery of siRNA and improving target gene knockdown.268