A self-adherent, bullet-shaped microneedle patch for controlled transdermal delivery of insulin

A bio-inspired, self-adherent microneedle (MN) patch is designed for effective transdermal protein drug delivery. The dual-functional MN patch achieved not only a firm adhesion to live animal skin tissue, but also a prolonged insulin drug delivery following a mild loading process into swellable tips with minimal loss of biofunctionality. This transdermal delivery platform using self-adherent MN patches can be applied for a variety of protein drugs requiring sustained release kinetics.247