Green design “bioinspired disassembly-reassembly strategy” applied for improved tumor-targeted anticancer drug delivery

A “bioinspired disassembly-reassembly strategy” was applied for RLNs-PTX preparation via an emulsion-evaporation method by using isolated human lipids and original proportions of endogenous apolipoproteins, thereby achieving efficient drug accumulation in cancer cells via multiple pathways, such as SR-BI-mediated direct translocation as well as LDLR- or LRP-induced endocytosis.195