Doxorubicin-induced co-assembling nanomedicines with temperature-sensitive acidic polymer and their in-situ-forming hydrogels for intratumoral administration

D-PNA100 nanomedicines are co-assembled by mixing PNA100 and doxorubicin hydrocloride (DOX·HCl). The co-assembly, along with temperature-sensitive sol-gel transition, play important role on prolonging retention time in tumor.411