Intracellular trafficking of bio-nanocapsule-liposome complex: Identification of fusogenic activity in the pre-S1 region of hepatitis B virus surface antigen L protein

BNC-LP complexes bind to HSPG, enter cells by high-affinity receptor, fuse with endosomal membrane by the pH-dependent fusogenic pre-S1 domain, and then release their payloads into the cytoplasm.232