Bioreducible core-crosslinked hyaluronic acid micelle for targeted cancer therapy

Core-crosslinked hyaluronic acid micelles can securely deliver doxorubicin into tumor cells after intravenous administration given their (i) robust blood stability, (ii) systemic accumulation, (iii) CD44-mediated cell permeation, and (iv) intracellular drug release by cleavage of the disulfide crosslinks in the micelle core.541