کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
7865926 | 1509131 | 2018 | 12 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Intracellular calcium ions and morphological changes of cardiac myoblasts response to an intelligent biodegradable conducting copolymer
ترجمه فارسی عنوان
یون های کلسیم داخل سلولی و تغییرات مورفولوژیکی پاسخ های میوبلاست های قلبی به یک کوپلیمر هدایت کننده زیست تخریب پذیر هوشمند
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
مهندسی مواد
بیومتریال
چکیده انگلیسی
A novel biodegradable conducting polymer, PLA-b-AP-b-PLA (PAP) triblock copolymer of poly (l-lactide) (PLA) and aniline pentamer (AP) with electroactivity and biodegradability, was synthesized and its potential application in cardiac tissue engineering was studied. The PAP copolymer presented better biocompatibility compared to PANi and PLA because of promoted cell adhesion and spreading of rat cardiac myoblasts (H9c2 cell line) on PAP/PLA thin film. After pulse electrical stimulation (5â¯V, 1â¯Hz, 500â¯ms) for 6â¯days, the proliferation ratio, and intracellular calcium concentration of H9c2 cells on PAP/PLA were improved significantly. Meanwhile, cell morphology changed by varying the pulse electrical signals. Especially, the oriented pseudopodia-like structure was observed from H9c2 cells on PAP/PLA after electrical stimulation. It is regarded that the novel conducting copolymer could enhance electronic signals transferring between cells because of its special electrochemical properties, which may result in the differentiation of cardiac myoblasts.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Materials Science and Engineering: C - Volume 90, 1 September 2018, Pages 168-179
Journal: Materials Science and Engineering: C - Volume 90, 1 September 2018, Pages 168-179
نویسندگان
Yu Wang, Wei Zhang, Lihong Huang, Yoshihiro Ito, Zongliang Wang, Xincui Shi, Yen Wei, Xiabin Jing, Peibiao Zhang,