کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
7868270 | 1509161 | 2016 | 14 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Synthesis and physicochemical characterization of chitin dihexanoate - A new biocompatible chitin derivative - In comparison to chitin dibutyrate
ترجمه فارسی عنوان
سنتز و مشخصات فیزیکوشیمیایی کیتین دی اکسیانات - یک مشتق از جدید کیتین زیست سازگار - در مقایسه با کیتین دی دیتریت
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کلمات کلیدی
بیوپلیمرها، پلی ساکارید، کیتین، استرینگ، بیومتریک،
موضوعات مرتبط
مهندسی و علوم پایه
مهندسی مواد
بیومتریال
چکیده انگلیسی
Chitin dihexanoate (DHCH) is the novel biocompatible and technologically friendly highly substituted chitin diester. Here we described optimization of DHCH and chitin dibutyrate (dibutyryl chitin, DBC) synthesis conditions (temperature and reaction time) to obtain desired polymers with high reaction yield, high substitution degree (close to 2) and appropriately high molecular weights. A two-step procedure, employing acidic anhydrides (hexanoic or butyric anhydride) as the acylation agent and methanesulfonic acid both as the catalyst and the reaction medium, was applied. Chemical structures of DBC and DHCH were confirmed by NMR (1H and 13C) and IR investigations. Mechanical properties, thermogravimetric analysis, differential scanning calorimetry and biocompatibility (Neutral red uptake assay, Skin Sensitization and Irritation Tests) were assessed. Both polymers proved highly biocompatible (non-cytotoxic in vitro, non-irritating and non-allergic to skin) and soluble in several organic solvents (dimethylformamide, N,N-dimethylacetamide, dimethyl sulfoxide, acetone, ethanol and others). It is worth emphasizing that DHCH and DBC can be easily processed by solvent casting method and the salt-leaching method, what gives the opportunity to prepare highly porous structures, which can be further successfully applied as the material for wound dressings and scaffolds for tissue engineering.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Materials Science and Engineering: C - Volume 60, 1 March 2016, Pages 489-502
Journal: Materials Science and Engineering: C - Volume 60, 1 March 2016, Pages 489-502
نویسندگان
Karolina SkoÅucka-Szary, Aleksandra RamiÄga, Wanda Piaskowska, Bartosz Janicki, Magdalena Grala, Piotr Rieske, Zbigniew Bartczak, Sylwester Piaskowski,