کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
7888921 | 1509797 | 2018 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Evaluation of the mechanical properties, in vitro biodegradability and cytocompatibility of natural chitosan/hydroxyapatite/nano-Fe3O4 composite
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
مهندسی مواد
سرامیک و کامپوزیت
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
The main goal of this research was the preparation and evaluation of the mechanical properties, in vitro biodegradability and cytocompatibility, of natural chitosan/hydroxyapatite/nano magnetite (nano-Fe3O4) composite. Different ratios of these components were investigated, including chitosan/hydroxyapatite: 4/4 (S1), chitosan/hydroxyapatite: 4/6 (S2), and chitosan/hydroxyapatite: 6/4 (S3). Mechanical properties of fabricated composites were examined using bending and compression tests before immersion, and after 2 and 9 weeks of immersion in the Ringer's solution. Scanning electron microscope (SEM) was employed for observing the bending fracture surface and analyzing the degradation morphology. Human mesenchymal stem cells (hMSC) were also cultured on the samples in order to assess the cytocompatibility. The obtained results revealed that S1 had the highest bending strength before immersion, while S3 had the highest bending strength after 9 weeks immersion. Compressive strength of S2 was greater than that of S1 and S3 not only before immersion, but also after 9 weeks immersion. Although the bio-minerals were deposited on the surface of all samples during the immersion in Ringer's solution, S2 appeared to have the highest quantity of bio-minerals. According to the weight loss percentage (ÎW(%)), the biodegradation resistance of S1 was the lowest. Finally, the cytocompatibility of S1 was greater than that of S2 and S3.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Ceramics International - Volume 44, Issue 1, January 2018, Pages 275-281
Journal: Ceramics International - Volume 44, Issue 1, January 2018, Pages 275-281
نویسندگان
Fatemeh Heidari, Mehdi Razavi, Mohammad E. Bahrololoom, Mostafa Yazdimamaghani, Mohammadreza Tahriri, Hari Kotturi, Lobat Tayebi,