کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8021229 | 1517271 | 2014 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
A novel integrated biphasic silk fibroin scaffold for intervertebral disc tissue engineering
ترجمه فارسی عنوان
یک رشته یکپارچه دوقطبی فیبرین ابریشم برای مهندسی بافت دیسک بین لگن
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
مهندسی بافت، دیسک بین مهره ای، فیلیپس انولوس، هسته پالپوس، فیبرن ابریشم، داربست دو جانبه،
موضوعات مرتبط
مهندسی و علوم پایه
مهندسی مواد
فناوری نانو (نانو تکنولوژی)
چکیده انگلیسی
The intervertebral disc (IVD) tissue engineering construct provides a promising approach for the treatment of symptomatic degenerative disc diseases. In this study, a novel 3D silk fibroin biphasic scaffold for integrated IVD tissue engineering was fabricated by sequentially using the paraffin sphere-leaching method for annulus fibrosus (AF) phase and the phase separation method for nucleus pulposus (NP) phase. Both phases were perfectly integrated and possessed a highly interconnected porous structure with pore size of 220±23.1 μm for AF and 90±17.8 μm for NP phase. Furthermore, the scaffolds were found to have a high porosity of 91% and 93% for AF and NP phases, respectively. In addition, this silk biphasic scaffold had a relative high compressive modulus under wet conditions (150.7±6.8 kPa). Rabbit AF and NP cells could attach, grow and further penetrate into the scaffold and distribute uniformly. This silk fibroin biphasic IVD scaffold emerges as a potential candidate for IVD tissue engineering.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Materials Letters - Volume 117, 15 February 2014, Pages 237-240
Journal: Materials Letters - Volume 117, 15 February 2014, Pages 237-240
نویسندگان
Lilong Du, Meifeng Zhu, Qiang Yang, Jiamin Zhang, Xinlong Ma, Deling Kong, Xiulan Li, Baoshan Xu, Lianyong Wang,