کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8131554 1523240 2014 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Application of 3-D Echocardiography and Gated Micro-Computed Tomography to Assess Cardiomyopathy in a Mouse Model of Duchenne Muscular Dystrophy
ترجمه فارسی عنوان
استفاده از سه بعدی اکوکاردیوگرافی و جابجایی میکروسکوپ الکترونی برای ارزیابی کاردیومیوپاتی در یک مدل ماوس دیستروفی عضلانی دوشن
موضوعات مرتبط
مهندسی و علوم پایه فیزیک و نجوم آکوستیک و فرا صوت
چکیده انگلیسی
The purpose of this study was to measure changes in cardiac function as cardiomyopathy progresses in a mouse model of Duchenne muscular dystrophy using 3-D ECG-gated echocardiography. This study is the first to correlate cardiac volumes acquired using 3-D echocardiography with those acquired using retrospectively gated micro-computed tomography (CT). Both were further compared with standard M-mode echocardiography and histologic analyses. We found that although each modality measures a decrease in cardiac function as disease progresses in mdx/utrn-/- mice (n = 5) compared with healthy C57BL/6 mice (n = 8), 3-D echocardiography has higher agreement with gold-standard measurements acquired by gated micro-CT, with little standard deviation between measurements. M-Mode echocardiography measurements, in comparison, exhibit considerably greater variability and user bias. Given the radiation dose associated with micro-CT and the geometric assumptions made in M-mode echocardiography to calculate ventricular volume, we suggest that use of 3-D echocardiography has important advantages that may allow for the measurement of early disease changes that occur before overt cardiomyopathy.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Ultrasound in Medicine & Biology - Volume 40, Issue 12, December 2014, Pages 2857-2867
نویسندگان
, , , , , , , , , , ,