کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8249018 | 1533350 | 2018 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Experimental optimisation of the X-ray energy in microbeam radiation therapy
ترجمه فارسی عنوان
بهینه سازی تجربی انرژی اشعه ایکس در پرتو درمان میکروب
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
فیزیک و نجوم
تشعشع
چکیده انگلیسی
Microbeam radiation therapy has demonstrated superior normal tissue sparing properties compared to broadbeam radiation fields. The ratio of the microbeam peak dose to the valley dose (PVDR), which is dependent on the X-ray energy/spectrum and geometry, should be maximised for an optimal therapeutic ratio. Simulation studies in the literature report the optimal energy for MRT based on the PVDR. However, most of these studies have considered different microbeam geometries to that at the Imaging and Medical Beamline (50â¯Î¼m beam width with a spacing of 400â¯Î¼m). We present the first fully experimental investigation of the energy dependence of PVDR and microbeam penumbra. Using monochromatic X-ray energies in the range 40-120â¯keV the PVDR was shown to increase with increasing energy up to 100â¯keV before plateauing. PVDRs measured for pink beams were consistently higher than those for monochromatic energies similar or equivalent to the average energy of the spectrum. The highest PVDR was found for a pink beam average energy of 124â¯keV. Conversely, the microbeam penumbra decreased with increasing energy before plateauing for energies above 90â¯keV. The effect of bone on the PVDR was investigated at energies 60, 95 and 120â¯keV. At depths greater than 20â¯mm beyond the bone/water interface there was almost no effect on the PVDR. In conclusion, the optimal energy range for MRT at IMBL is 90-120â¯keV, however when considering the IMBL flux at different energies, a spectrum with 95â¯keV weighted average energy was found to be the best compromise.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Physica Medica - Volume 45, January 2018, Pages 156-161
Journal: Physica Medica - Volume 45, January 2018, Pages 156-161
نویسندگان
Jayde Livingstone, Andrew W. Stevenson, Daniel Häusermann, Jean-François Adam,