Genetically elevated gamma-glutamyltransferase and Alzheimer's disease

The odds ratio of AD was 1.09 (95% confidence interval, 0.98 to 1.22; p  =  0.10) per one standard deviation genetically elevated GGT based on all 26 SNPs. The results were similar in both MR-Egger and weighted median MR methods. Overall, our findings cannot confirm a strong causal effect of GGT on AD risk. Further MR investigations using individual-level data are warranted to confirm or rule out causality.