کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8262345 | 1534836 | 2018 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Human neuromuscular aging: Sex differences revealed at the myocellular level
ترجمه فارسی عنوان
پیری انسانی عضلانی: اختلالات جنسی در سطح قلب مشاهده شده است
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
سالمندی
چکیده انگلیسی
Age-related muscle loss (sarcopenia) is a major clinical problem affecting both men and women - accompanied by muscle weakness, dysfunction, disability, and impaired quality of life. Current definitions of sarcopenia do not fully encompass the age-related changes in skeletal muscle. We therefore examined the influence of aging and sex on elements of skeletal muscle health using a thorough histopathological analysis of myocellular aging and assessments of neuromuscular performance. Two-hundred and twenty-one untrained males and females were separated into four age cohorts [mean age 25â¯y (nâ¯=â¯47), 37â¯y (nâ¯=â¯79), 61â¯y (nâ¯=â¯51), and 72â¯y (nâ¯=â¯44)]. Total (â12%), leg (â17%), and arm (â21%) lean mass were lower in both 61â¯y and 72â¯y than in 25â¯y or 37â¯y (Pâ¯<â¯0.05). Knee extensor strength (â34%) and power (â43%) were lower (Pâ¯<â¯0.05) in the older two groups, and explosive sit-to-stand power was lower by 37â¯y (Pâ¯<â¯0.05). At the histological/myocellular level, type IIx atrophy was noted by 37â¯y and type IIa atrophy by 61â¯y (Pâ¯<â¯0.05). These effects were driven by females, noted by substantial and progressive type IIa and IIx atrophy across age. Aged female muscle displayed greater within-type myofiber size heterogeneity and marked type I myofiber grouping (~5-fold greater) compared to males. These findings suggest the predominant mechanisms leading to whole muscle atrophy differ between aging males and females: myofiber atrophy in females vs. myofiber loss in males. Future studies will be important to better understand the mechanisms underlying sex differences in myocellular aging and optimize exercise prescriptions and adjunctive treatments to mitigate or reverse age-related changes.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Experimental Gerontology - Volume 106, June 2018, Pages 116-124
Journal: Experimental Gerontology - Volume 106, June 2018, Pages 116-124
نویسندگان
Brandon M. Roberts, Kaleen M. Lavin, Gina M. Many, Anna Thalacker-Mercer, Edward K. Merritt, C. Scott Bickel, David L. Mayhew, S. Craig Tuggle, James M. Cross, David J. Kosek, John K. Petrella, Cynthia J. Brown, Gary R. Hunter, Samuel T. Windham,